Rheumatoid Arthritis Risk Allele PTPRC Is Also Associated With Response to Anti–Tumor Necrosis Factor Therapy
نویسندگان
چکیده
Jing Cui, Saedis Saevarsdottir, Brian Thomson, Leonid Padyukov, Annette H. M. van der Helm-van Mil, Joanne Nititham, Laura B. Hughes, Niek de Vries, Soumya Raychaudhuri, Lars Alfredsson, Johan Askling, Sara Wedrén, Bo Ding, Candace Guiducci, Gert Jan Wolbink, J. Bart A. Crusius, Irene E. van der Horst-Bruinsma, Marieke Herenius, Michael E. Weinblatt, Nancy A. Shadick, Jane Worthington, Franak Batliwalla, Marlena Kern, Ann W. Morgan, Anthony G. Wilson, John D. Isaacs, Kimme Hyrich, the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, Michael F. Seldin, Larry W. Moreland, Timothy W. Behrens, Cornelia F. Allaart, Lindsey A. Criswell, Tom W. J. Huizinga, Paul P. Tak, S. Louis Bridges, Jr., Rene E. M. Toes, Anne Barton, Lars Klareskog, Peter K. Gregersen, Elizabeth W. Karlson, and Robert M. Plenge
منابع مشابه
TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy
BACKGROUND The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response. METHODS We evaluated associations between anti-TNF treatment res...
متن کاملRheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.
OBJECTIVE Anti-tumor necrosis factor alpha (anti-TNF) therapy is a mainstay of treatment in rheumatoid arthritis (RA). The aim of the present study was to test established RA genetic risk factors to determine whether the same alleles also influence the response to anti-TNF therapy. METHODS A total of 1,283 RA patients receiving etanercept, infliximab, or adalimumab therapy were studied from a...
متن کاملReplication of Association of the PTPRC Gene With Response to Anti–Tumor Necrosis Factor Therapy in a Large UK Cohort
OBJECTIVE Several rheumatoid arthritis (RA) susceptibility variants map close to genes involved in the tumor necrosis factor (TNF) signaling pathway, prompting the investigation of RA susceptibility variants in studies of predictors of response to TNF blockade. Based on a previously reported association of RA with the PTPRC genetic locus, the present study was undertaken to test established RA ...
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Treatment strategies blocking tumor necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA), showing beneficial effects in approximately 50-60% of the patients. However, a significant subset of patients does not respond to anti-TNF agents, for reasons that are still unknown. The aim of this study was to validate five single nucleotide polymorphisms (SNP...
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Background: Periodontitis and rheumatoid arthritis (RA) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (TNF-α)-induced bone resorption that is involved in the pathogenesis of both. Objectives: To investigate the effect of TNF-α blockade on periodontal conditions in patients with active RA. Method: The periodontal statuses of 3...
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